참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,6-Dichloro-4-(trifluoromethyl)pyridine | HCID 520968 | — |
| 반응물 | Sodium hydroxide methanol | HCID 23721981 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Chloro-6-methoxy-4-(trifluoromethyl)pyridine | HCID 56832314 | 99.9% |
반응 단계
To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08895568B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-b5c7d2dfeb7549569c8b8a811368072d |
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| 출처 메모 | uspto-grants-2014_11 |
|---|
