Tetramethyl orthocarbonate → 5-(3-Bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide

HRID 339839

반응식

HRID 339839 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([S:13]([NH2:16])(=[O:15])=[O:14])[C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[CH3:17][O:18][C:19](OC)(OC)OC>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:9]([CH3:10])([CH3:11])[O:12][C:17]([O:18][CH3:19])=[N:16][S:13]2(=[O:14])=[O:15])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 74613Tetramethyl orthocarbonateHCID 682918601-(3-Bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide

생성물 1

HCID 683592025-(3-Bromophenyl)-2-methoxy-6,6-dimethyl-5,6-dihydro-1,4,3-oxathiazine 4,4-dioxide

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 500 mg of 1-(3-bromophenyl)-2-hydroxy-2-methylpropane-1-sulfonamide in 2 ml of tetramethoxymethane and 0.5 ml of acetic acid was stirred at 100° C. for 3 hours. After the removal of the solvent under reduced pressure, the residue (565 mg) was used in the next reaction without further purification.

후처리

  1. customAfter the removal of the solvent under reduced pressure
  2. customthe residue (565 mg) was used in the next reaction without further purification

출처 및 근거

ORD 기록
ord-da8c1461b04e494cb05814fd65140e10
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895547B2

연결된 노트

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