Methyl propiolate → HCID 86681478, 화합물

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[NH2:1]/[C:2](/[CH3:9])=[CH:3]\[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:10]([O:14][CH3:15])(=[O:13])[C:11]#[CH:12]>>[NH2:1]/[C:2](=[C:3](\[C:4]([O:6][CH2:7][CH3:8])=[O:5])/[CH:12]=[CH:11]/[C:10]([O:14][CH3:15])=[O:13])/[CH3:9]

참가 물질

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HCID 13536Methyl propiolate

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-

생성물 1

HCID 86681478HCID 86681478, 화합물수율 93.8%

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온도: 110 °C

실험 절차

Ethyl (2Z)-3-aminobut-2-enoate (6.46 g, 50.0 mmol) and methyl propiolate (4.20 g, 50.0 mmol) were mixed in one 100 mL flask, and the mixture was stirred at 110° C. for 10 hrs. The reaction mixture was cooled to room temperature and recrystallized with methanol to give 10 g (93% yield) of the pure product. LC-MS found: 214.2.1 (M+H)+.

후처리

temperatureThe reaction mixture was cooled to room temperature
customrecrystallized with methanol

출처 및 근거

ORD 기록: ord-67075832b21741ac8627a8bdcca638b1
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08895571B2

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