Potassium Hydroxide → 5-(2-Fluorophenoxy)-2-pyrazinecarboxylic acid

HRID 340092노트

반응식

HRID 340092 반응식
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[CH:7][N:6]=1)=[O:4].[OH-].[K+]>C(O)C>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[O:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 71238257HCID 71238257, 화합물

생성물 1

HCID 463182515-(2-Fluorophenoxy)-2-pyrazinecarboxylic acid수율 51.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-(2-Fluoro-phenoxy)-pyrazine-2-carboxylic acid methyl ester (Preparation 44, 57.9 g, 233 mmol) was added to a solution of KOH (15 g, 267 mmol) in 78% ethanol (330 mL). The solution was stirred at room temperature for 18 hours, and the formed precipitate was collected by filtration. The resulting solid was dissolved in water (200 mL), and the solution was acidified with aqueous hydrochloric acid. The formed precipitate was collected by filtration, dried and recrystallised from 41% ethanol (265 mL) to give the title compound (28.3 g, 120.8 mmol) in 51.8% yield.

후처리

  1. filtrationthe formed precipitate was collected by filtration
  2. dissolutionThe resulting solid was dissolved in water (200 mL)
  3. filtrationThe formed precipitate was collected by filtration
  4. customdried
  5. customrecrystallised from 41% ethanol (265 mL)

출처 및 근거

ORD 기록
ord-318af253e5ac47f987cfe7f46a9f65f9
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895544B2

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