Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloro-5-(trifluoromethyl)picolinaldehyde oxime → 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloro-5-(trifluoromethyl)picolinaldehyde oxime | HCID 718249 | — |
| 반응물 | Methyl N-(triethylammoniosulfonyl)carbamate | HCID 2724994 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-Chloro-5-(trifluoromethyl)pyridine-2-carbonitrile | HCID 1473374 | — |
반응 단계
A solution of 3-chloro-5-(trifluoromethyl)picolinaldehyde oxime (1.0 eq.) and Burgess reagent (1.5 eq.) in tetrahydrofuran (0.5 M) was heated to 65° C. and stirred for 1 hour. The reaction was cooled to room temperature and diluted with ethyl acetate and water. The organic layer was washed with water, brine, dried over anhydrous MgSO4, and concentrated en vacuo to give a solid that was carried onto the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895577B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-60b799d726c742ca8d4da0ea1566b81f |
| 출처 메모 | uspto-grants-2014_11 |