Cesium fluoride → 5-Bromo-2,3-difluorobenzaldehyde
반응식
[Br:1][C:2]1[C:3]([Si](C)(C)C)=[C:4]([F:11])[C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[F-].[Cs+]>CN(C)C=O.O.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8]참가 물질
6
실험 절차
To a solution of 18.0 g of 5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde in 20 mL of N,N-dimethylformamide and 2 mL of water was added 1.63 g of cesium fluoride at room temperature, and stirred at this temperature for 1 hour. After diluting with ethyl acetate, the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 10.26 g of the title compound as a colorless oil.
후처리
- washthe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-fddcc1bba83a4ad4804828b8fcf6c8d4
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07429609B2
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