Ammonia → HCID 178522272, 화합물

HRID 34030

반응식

HRID 34030 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:26][C:27]([C:29]2[O:30][CH:31]=[CH:32][CH:33]=2)=[O:28])[CH:5]=[C:6]2[C:10]=1[N:9](C(C1OC=CC=1)=O)[N:8]=[C:7]2/[CH:18]=[CH:19]/[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1.N>C(O)C.[Cl-].[Na+].O>[F:1][C:2]1[CH:3]=[C:4]([NH:26][C:27]([C:29]2[O:30][CH:31]=[CH:32][CH:33]=2)=[O:28])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[CH:18]=[CH:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 59797182Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide

생성물 1

HCID 178522272HCID 178522272, 화합물수율 58.7%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 57417360Sodium chloride; water용매

실험 절차

208 mg of furan-2-carboxylic acid{7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-yl}-amide was suspended in 20 mL ethanol, added with 5 mL of concentrated aqueous ammonia and stirred at room temperature overnight. The reaction solution was added with saturated brine, extracted with ethyl acetate, and the organic phase was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated, purified by LC-MS and the obtained crystals were suspended in ethyl acetate, neutralized with saturated aqueous sodium hydrogen carbonate, and the organic phase was washed with water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated, to afford 96.2 mg of the title compound as yellow crystals.

후처리

  1. extractionextracted with ethyl acetate
  2. washthe organic phase was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated
  5. custompurified by LC-MS
  6. washthe organic phase was washed with water and saturated brine
  7. dry with materialdried over magnesium sulfate
  8. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-e573073fc06345ba9a52f5d3cadd9a76
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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