Thionyl Chloride → HCID 86652358, 화합물

HRID 340334노트

반응식

HRID 340334 반응식
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539, 화합물

생성물 1

HCID 86652358HCID 86652358, 화합물

실험 절차

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vacuo. The crude material was used for next step without purification.

후처리

  1. concentrationthe reaction mixture was concentrated en vacuo
  2. customThe crude material was used for next step without purification

출처 및 근거

ORD 기록
ord-611b483cfb9e44098db8337c0b78f391
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895577B2

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