Acetic Acid → HCID 59797236, 화합물

HRID 34034노트

반응식

HRID 34034 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][N:8]2C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:4][C:3]=1[NH2:39].[C:40]([OH:43])(=O)[CH3:41]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=3)=[N:7][NH:8]2)=[CH:4][C:3]=1[NH:39][C:40](=[O:43])[CH3:41]

참가 물질

3

반응물 2

HCID 176Acetic AcidHCID 68932237HCID 68932237, 화합물

생성물 1

HCID 59797236HCID 59797236, 화합물

실험 절차

525 mg of 6-fluoro-3-[(E)-2-(3-fluorophenyl)-vinyl]-1-trityl-1H-indazol-5-ylamine and 80 μl of glacial acetic acid were dehydraing-condensed in accordance with Example 127, followed by deprotection in the similar method as described in Example 16, to afford 150 mg of the title compound as bright yellow crystals.

후처리

  1. customdehydraing-condensed in accordance with Example 127

출처 및 근거

ORD 기록
ord-63b07e23401b4d93b02ac0c3d93b842e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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