Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-methoxy-N-propargyl-p-chlorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Propargyl bromide | HCID 7842 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-chloro-N-methoxybenzamide | HCID 12610570 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-methoxy-N-propargyl-p-chlorobenzamide | HCID 18935031 | 36.5% |
반응 단계
0.22 g of sodium hydride (60% in oil) was suspended in 10 ml of tetrahydrofuran, and 1.0 g of N-methoxy-p-chlorobenzamide and 0.68 g of propargyl bromide were added thereto in this order while being cooled with ice. The mixture was heat-refluxed for 8 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.44 g of N-methoxy-N-propargyl-p-chlorobenzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733935 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-70e031461ff64ee8941f84d430c91d71 |
| 출처 메모 | uspto-grants-1998_03 |