Ethanol → CID 59797354

HRID 34044노트

반응식

HRID 34044 반응식
[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[N:6][NH:7]2.[CH2:15](O)[CH3:16]>O>[CH2:15]([O:13][C:12]([C:11]1[C:3]([O:2][CH3:1])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)=[O:14])[CH3:16]

참가 물질

4

반응물 2

HCID 702EthanolHCID 23070119CID 23070119

생성물 1

HCID 59797354CID 59797354

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
95 °C

실험 절차

2 g of 4-methoxy-1H-indazole-5-carboxylic acid was added to a mixed solvent of 40 mL ethanol/2.2 mL concentrated sulfuric acid, and stirred at 95° C. for 11 hours. After cooling the reaction solution on ice, water was slowly added under ice cooling, and the precipitated crystals were collected by filtration and washed with water. Thereafter, the crystals were dried under reduced pressure, to afford 1.52 g of the title compound as pale brown crude crystals.

후처리

  1. additionwas slowly added under ice cooling
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customThereafter, the crystals were dried under reduced pressure

출처 및 근거

ORD 기록
ord-29bbec0e7d9247aab261bd096818d609
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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