참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Bromopyridine | HCID 12286 | — |
| 반응물 | Phosphine, tris(4-methylphenyl)- | HCID 13956 | — |
| 반응물 | 3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile | HCID 23070127 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 4-Methoxy-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carbonitrile | HCID 68928542 | — |
반응 단계
300 mg of 3-vinyl-4-methoxy-1-trityl-1H-indazole-5-carbonitrile and 180 μl of 3-bromopyridine were dissolved in a mixed solvent of 1 mL triethylamine/5 mL acetonitrile, added with 40 mg of tri-p-tolylphosphine and 27 mg of palladium acetate (II), and heated at 110° C. for 24 hours. The reaction solution was added with silica gel, the solvent was evaporated, and the resultant residue was purified by column chromatography (hexane:ethyl acetate=7:3), to afford 120 mg of the title compound as a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429609B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-4110f144624145549fb126ad24035122 |
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| 출처 메모 | uspto-grants-2008_09 |
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