4-(4-Nitrophenyl)piperidine-2,6-dione → 4-(4-Aminophenyl)piperidine-2,6-dione
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][C:14](=[O:16])[NH:13][C:12](=[O:17])[CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[CH2:11][C:12](=[O:17])[NH:13][C:14](=[O:16])[CH2:15]2)=[CH:8][CH:9]=1참가 물질
4
실험 절차
A solution of 197 mg (0.841 mmol) of 4-(4-nitro-phenyl)-piperidine-2,6-dione (as prepared in the previous step) in methyl alcohol (MeOH) (15 mL) was hydrogenated over 10% Pd/C at 20 psi for 5 h at RT. The mixture was filtered through Celite, the filter cake was washed with MeOH, and the solvents were evaporated in vacuo to afford 106 mg (62%) of the title compound as an off-white solid: Mass spectrum (ESI, m/z): Calcd. for C11H12N2O2, 205.1 (M+H). found 205.1.
후처리
- filtrationThe mixture was filtered through Celite
- washthe filter cake was washed with MeOH
- customthe solvents were evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-96e3694ad8af447fa52bd5691f25e18e
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08895584B2
반응 노트
불러오는 중…