Water → N-methoxy-N-propargyloxymethylbenzamide
반응식
[CH3:1][O:2][NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:19][O:20][CH2:21][C:22]#[CH:23].O>C(#N)C>[CH3:1][O:2][N:3]([CH2:19][O:20][CH2:21][C:22]#[CH:23])[C:4](=[O:11])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1참가 물질
6
실험 절차
0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.
후처리
- additionwas added to the reaction solution
- extractionthe mixture was extracted with ethyl acetate
- customThe extract was dried
- concentrationconcentrated
- custompurified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-78a2d25f14b9434b93e8ef7743620d47
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05733935
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