참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diiodomethane | HCID 6346 | — |
| 반응물 | 2-Amino-4-methyl-5-nitropyridine | HCID 243165 | — |
| 반응물 | Isopentyl sulfite | HCID 22742080 | — |
| 생성물 | 2-Iodo-4-methyl-5-nitropyridine | HCID 23070167 | — |
반응 단계
To a solution of 1.0 g of 2-amino-4-methyl-5-nitropyridine in 10 mL of diiodomethane was added 1.8 mL of isopentyl sulfite at room temperature, stirred at this temperature for 30 minutes, and after raising the temperature to 80° C., the solution was stirred for 2 hours. The diiodomethane was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:20), to afford 897 mg of the title compound as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429609B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-4591426222324116a52532a1d4076497 |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
