Triacetoxyperiodinane → 5-Chloro-4-formylthiophene-2-carbonitrile

HRID 34073노트

반응식

HRID 34073 반응식
[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][C:3]=1[CH2:9][OH:10].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][C:3]=1[CH:9]=[O:10]

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 230701655-Chloro-4-hydroxymethylthiophene-2-carbonitrile

생성물 1

HCID 230702115-Chloro-4-formylthiophene-2-carbonitrile수율 151.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 3.0 g of 5-chloro-4-hydroxymethylthiophene-2-carbonitrile in 34 mL of dichloromethane was added 8.06 g of Dess-Martin reagent at room temperature, and stirred at this temperature for a day. After diluting with dichloromethane, washing successively with aqueous sodium hydrogen carbonate and saturated brine, and drying over anhydrous magnesium sulfate, the solvent was evaporated, to afford 4.5 g of a crude product of the title compound as colorless crystals.

후처리

  1. washwashing successively with aqueous sodium hydrogen carbonate and saturated brine
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-fc6f0aba60704c4dabaaa80653a14acb
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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