Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1H-thieno[2,3-c]pyrazole-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile | HCID 68927237 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 1H-thieno[2,3-c]pyrazole-5-carbonitrile | HCID 68926994 | 100.2% |
반응 단계
To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429609B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-fe2c8efc4b0447988675b250e4cc7df3 |
| 출처 메모 | uspto-grants-2008_09 |