Hydrazine → Isoquinoline-3-carbohydrazide

HRID 340886

반응식

HRID 340886 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]C)=O)[N:2]=1.[NH2:15][NH2:16]>C(O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([NH:15][NH2:16])=[O:13])[N:2]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 725374Methyl 3-isoquinolinecarboxylate

생성물 1

HCID 55263898Isoquinoline-3-carbohydrazide수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

후처리

  1. temperatureThe reaction mixture was refluxed for 30 min
  2. concentrationconcentrated under high vacuum
  3. customto remove hydrazine
  4. customThe resulting residue was triturated with ethanol (20 mL)

출처 및 근거

ORD 기록
ord-326e316ddfb74c1f8b140e81d1113f34
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895582B2

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