Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 34091생성일: 2026년 10월 23일
3-(Dimethylamino)-2-propenal → 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole
https://huagongshe.com/ko/reaction/34091
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(Dimethylamino)-2-propenal | HCID 79125 | — |
| 반응물 | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine Hydrochloride | HCID 68928009 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole | HCID 60034727 | — |
반응 단계
36 mg of 6-fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine hydrochloride obtained by Example 599 and 15 μl of 3-dimethylaminopropenal were dissolved in 1 mL of pyridine, and stirred at 120° C. for 7 hours. After distilling off the solvent, purification by LC-MS was conducted, to give 0.61 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07429609B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-eba3391fdedb4d1195f66eec34e10ce3 |
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| 출처 메모 | uspto-grants-2008_09 |
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