Water → ethyl 5-bromo-2H-indazole-3-carboxylate

HRID 34093노트

반응식

HRID 34093 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.O.[C:20](OCC)(=O)[CH3:21]>C(O)C>[CH2:20]([O:12][C:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=2)[NH:7][N:6]=1)=[O:13])[CH3:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 8857Ethyl AcetateHCID 71573585-bromo-1H-indazole-3-carboxylic Acid

생성물 1

HCID 12689364ethyl 5-bromo-2H-indazole-3-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3 g of 5-bromo-1H-indazole-3-carboxylic acid was dissolved in 60 mL of ethanol, added with 0.6 mL of concentrated sulfuric acid, and heated under reflux for 8 hours. After allowing to cool to room temperature, addition of water and extraction with ethyl acetate were conducted, and the resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine, dried over magnesium sulfate, and the solvent was evaporated, to afford 2.7 g of the title compound as yellow crystals.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. washthe resultant organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-d77850c85fd540af9825519a7b12cb14
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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