Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → [Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic Acid Tert-Butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | tert-Butyl carbamate | HCID 77922 | — |
| 반응물 | Sodium 4-methylbenzenesulfonate | HCID 3720192 | — |
| 반응물 | 1,3-Oxazole-2-carboxaldehyde | HCID 14786609 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | [Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic Acid Tert-Butyl Ester | HCID 60034835 | 24.7% |
반응 단계
300 mg of oxazole 2-carboaldehyde was dissolved in a mixed solvent of 3 mL of methanol and 6 mL of water, added successively with 363 mg of tert-butyl carbamate, 552 mg of sodium p-toluenesulfonate and 0.76 mL of formic acid and stirred at room temperature for 16 hours and 30 minutes. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure, to afford 247 mg of the title compound as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429609B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-3b7aa62a381549e18666f9b8cf1832d0 |
| 출처 메모 | uspto-grants-2008_09 |