Formic Acid → [Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic Acid Tert-Butyl Ester

HRID 34103

반응식

HRID 34103 반응식
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=O.[C:8](=[O:15])([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[NH2:9].[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([O-])(=[O:24])=[O:23])=[CH:18][CH:17]=1.[Na+].C(O)=O>CO.O>[C:11]([O:10][C:8](=[O:15])[NH:9][CH:6]([C:2]1[O:1][CH:5]=[CH:4][N:3]=1)[S:22]([C:19]1[CH:20]=[CH:21][C:16]([CH3:26])=[CH:17][CH:18]=1)(=[O:24])=[O:23])([CH3:14])([CH3:13])[CH3:12]

참가 물질

7

반응물 4

HCID 284Formic AcidHCID 77922tert-Butyl carbamateHCID 3720192Sodium 4-methylbenzenesulfonateHCID 147866091,3-Oxazole-2-carboxaldehyde

생성물 1

HCID 60034835[Oxazol-2-yl-(toluene-4-sulfonyl)-methyl]-carbamic Acid Tert-Butyl Ester수율 24.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

300 mg of oxazole 2-carboaldehyde was dissolved in a mixed solvent of 3 mL of methanol and 6 mL of water, added successively with 363 mg of tert-butyl carbamate, 552 mg of sodium p-toluenesulfonate and 0.76 mL of formic acid and stirred at room temperature for 16 hours and 30 minutes. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure, to afford 247 mg of the title compound as colorless crystals.

후처리

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-3b7aa62a381549e18666f9b8cf1832d0
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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