Methanol → 3-(6-(4-methoxyphenyl)-9H-pyrido[2,3-b]indol-3-yl)benzenamine

HRID 341300노트

반응식

HRID 341300 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]2[N:18]=[CH:19][C:20]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=4)=[CH:21][C:12]3=2)=[CH:5][CH:4]=1.CO>C1COCC1.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]2[N:18]=[CH:19][C:20]([C:22]4[CH:23]=[C:24]([NH2:28])[CH:25]=[CH:26][CH:27]=4)=[CH:21][C:12]3=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 461841576-(4-methoxyphenyl)-3-(3-nitrophenyl)-9H-pyrido[2,3-b]indole

생성물 1

HCID 461841583-(6-(4-methoxyphenyl)-9H-pyrido[2,3-b]indol-3-yl)benzenamine수율 79%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

6-(4-methoxyphenyl)-3-(3-nitrophenyl)-9H-pyrido[2,3-b]indole (35 mg, 0.09 mmol, 1 equiv.), is dissolved in anhydrous THF (1 ml), MeOH (8 ml), and palladium on charcoal (10 mg, 0.009 mmol, 0.1 equiv.), are then added in an autoclave which is flushed with argon and then pressurized with H2 (10 bar). The reaction is carried out at room temperature for 16 hours. The mixture is then filtered over Mite and washed with AcOEt. The green solid obtained is washed with methanol to afford the product as a slightly green solid (26 mg, 0.07 mmol), in 79% yield.

후처리

  1. customis flushed with argon
  2. filtrationThe mixture is then filtered over Mite
  3. washwashed with AcOEt
  4. customThe green solid obtained
  5. washis washed with methanol

출처 및 근거

ORD 기록
ord-df18fe136c4e4c60a09cf37173a793e2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895744B2

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