Water → 3-Azidopiperidin-2-one

HRID 34135노트

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HRID 34135 반응식
Br[CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].[N-:9]=[N+:10]=[N-:11].[Na+].O>CN(C)C=O>[N:9]([CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8])=[N+:10]=[N-:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 1181713-Bromopiperidin-2-one

생성물 1

HCID 230701363-Azidopiperidin-2-one수율 56.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2.0 g of 3-bromopiperidin-2-one in 30 ml of N,N-dimethylformamide was added 5.9 g of sodium azide, followed by stirring at 60° C. overnight. After cooling down to room temperature, water was added to the reaction mixture and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 890 mg of the title compound as a yellow oil.

후처리

  1. temperatureAfter cooling down to room temperature
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-4b22bc59313e4936ae5b7c24eb6c20e4
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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