Sodium Iodide → HCID 57608436, 화합물

HRID 341596노트

반응식

HRID 341596 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([OH:12])[CH2:10]Cl)[CH:5]=[CH:6][CH:7]=1.[N-:13]=[N+:14]=[N-:15].[Na+].[Na+].[I-]>CN(C=O)C.CCOCC>[N:13]([CH2:10][CH:9]([OH:12])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)=[N+:14]=[N-:15]

참가 물질

6

반응물 3

HCID 5238Sodium IodideHCID 33557Sodium AzideHCID 576084881-(3-Bromophenyl)-3-chloropropan-2-ol

생성물 1

HCID 57608436HCID 57608436, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

반응 조건

온도
75 °C

실험 절차

To a solution of 1-(3-bromophenyl)-3-chloropropan-2-ol (8.49 g, 34.0 mmol) in anhydrous DMF (100 mL) under N2 was added NaN3 (11.05 g, 170.0 mmol) and NaI (cat., 0.75 g, 5.0 mmol). The mixture was heated at 75° C. overnight. After cooling to room temperature, the mixture was diluted with ether and washed with water and brine. The solution was dried over Na2SO4 and concentrated under reduced pressure. The product was dried in a vacuum oven at 40° C. for 2 h to give 1-azido-3-(3-bromophenyl)propan-2-ol as a yellow oil which was used without purification. Yield (8.6 g, 98% crude).

후처리

  1. temperatureAfter cooling to room temperature
  2. washwashed with water and brine
  3. dry with materialThe solution was dried over Na2SO4
  4. concentrationconcentrated under reduced pressure
  5. customThe product was dried in a vacuum oven at 40° C. for 2 h

출처 및 근거

ORD 기록
ord-df8be66458c74ee3b620f77ecd3ca9cb
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895782B2

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