Water → N-(4-bromo-2-ethylphenyl)acetamide

HRID 341683

반응식

HRID 341683 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH3:10])[CH:3]=1.C(N(CC)CC)C.[C:18](Cl)(=[O:20])[CH3:19].O>ClCCl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:18](=[O:20])[CH3:19])=[C:4]([CH2:9][CH3:10])[CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 28012834-Bromo-2-ethylaniline

생성물 1

HCID 2735223N-(4-bromo-2-ethylphenyl)acetamide수율 66.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromo-2-ethylaniline (50 g, 0.25 mol) in dichloromethane (250 ml) is added triethylamine (63.24 g, 0.62 mol) and the mixture is stirred at room temperature for 30 minutes. The reaction mixture is cooled to 0° C. and acetyl chloride (39.25 g, 0.5 mol) is added dropwise. The reaction mixture is stirred at 25-30° C. for 60 minutes, then poured into water, and the two phases separated. The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered and the filtrate is evaporated under reduced pressure to yield N-(4-bromo-2-ethylphenyl)acetamide (40 g).

후처리

  1. temperatureThe reaction mixture is cooled to 0° C.
  2. stirringThe reaction mixture is stirred at 25-30° C. for 60 minutes
  3. customthe two phases separated
  4. washThe organic phase is washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customthe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ab06096ecef34f869695e9d0f193cf6a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895761B2

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