Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178520660, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 1-(Thiazol-2-yl)piperazine | HCID 911806 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline | HCID 68938489 | — |
| 용매 | Acetonitrile tetrahydrofuran | HCID 22177404 | — |
| 생성물 | HCID 178520660 | HCID 178520660 | — |
반응 단계
Prepared analogously to Example 61 from 6-chloro-4-[1-(1-tert.-butyloxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonyl-propyl-amino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline and 1-thiazol-2-yl-piperazine with TBTU in acetonitrile/tetrahydrofuran and subsequent reaction with trifluoroacetic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429597B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-2e78196ce9ec4382b21f342b6146027a |
| 출처 메모 | uspto-grants-2008_09 |