Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178468882, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Ethyl piperidine-2-carboxylate | HCID 27517 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Pentafluorphenol-tetramethyluronium hexafluorophosphat | HCID 15840204 | — |
| 반응물 | 6-chloro-4-(1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline | HCID 178463504 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | HCID 178468882 | HCID 178468882 | — |
반응 단계
Prepared analogously to Example 37a from 6-chloro-4-[1-(5-chloro-1H-benzimidazol-2-yl)-ethylamino]-7-hydroxycarbonyl-quinazoline, pentafluorophenyl-tetramethyluronium-hexafluorophosphate (PFTU), diisopropylethylamine and ethyl piperidine-2-carboxylate in DMSO at ambient temperature and subsequent treatment with trifluoroacetic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429597B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-fe4693af300d4a769fffbd80f90d5568 |
| 출처 메모 | uspto-grants-2008_09 |