Pyridine → 2-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester

HRID 341809

반응식

HRID 341809 반응식
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].C[CH:17](O)[C:18]([O-:20])=[O:19].N1C=CC=C[CH:23]=1>C(Cl)Cl>[S:3]([O:6][CH2:17][C:18]([O:20][CH3:23])=[O:19])([C:2]([F:15])([F:14])[F:1])(=[O:5])=[O:4]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 67749Trifluoromethanesulfonic anhydrideHCID 91435Lactate

생성물 1

HCID 112297732-(((Trifluoromethyl)sulfonyl)oxy)acetic acid methyl ester수율 90%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

10.09 ml (60 mmol) trifluorometansulfonic anhydrid dissolved in CH2Cl2 was added dropwise to a mixture of 4.05 ml (50 mmol) methylglycolate and 4.04 ml (50 mmol) pyridin in CH2Cl2 (totally 62.5 ml) at 0° C. during 25 minutes, and thereafter stirred at 0° C. for 1 H. After washing with 0.3M KHSO4 and saturated NA2CO3, drying (Na2SO4) and filtration, evaporation of the solvent in vacuo gave 9.94 g (90%) of the title compound.

후처리

  1. washAfter washing with 0.3M KHSO4 and saturated NA2CO3
  2. customdrying
  3. filtration(Na2SO4) and filtration, evaporation of the solvent in vacuo

출처 및 근거

ORD 기록
ord-ed848f084cb34979af6207996e646ec0
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856307

연결된 노트

불러오는 중…