5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol → 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

HRID 341829노트

반응식

HRID 341829 반응식
[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CO>CCOCC.ClCCl>[ClH:22].[C:1]1([CH2:7][CH2:8][C:9]2[N:19]3[C:20]4[C:15]([CH:16]([OH:21])[CH2:17][CH2:18]3)=[CH:14][CH:13]=[CH:12][C:11]=4[N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 98604535,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-olHCID 21893726Hydrochloride methanol

생성물 1

HCID 675964275,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

A portion (0.2 g) of 5,6-dihydro-2-(2-phenylethyl)-4H-imidazo[4,5,1-ij]quinolin-6-ol obtained in Example 4 was dissolved in ether (10 mL) and dichloromethane (10 mL); following the addition of 10% HCl-methanol solution (0.5 g), the solvents were removed under reduced pressure, followed by crystallization from ether; upon filtration, the titled compound was obtained as colorless crystals (0.23 g).

후처리

  1. customthe solvents were removed under reduced pressure
  2. customfollowed by crystallization from ether
  3. filtrationupon filtration

출처 및 근거

ORD 기록
ord-13d96a448e5a4c50ba187adf97220eb7
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856334

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