Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzaldehyde, 4-hydroxy-3-iodo-5-methoxy- | HCID 79499 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Iodo-4,5-dimethoxybenzaldehyde | HCID 2778113 | — |
반응 단계
A mixture of 5-iodovanillin (7 g, 25.18 mmole), potassium carbonate (8.78 g, 63.53 mmole) and iodomethane (6.43 g, 45.30 mmole) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856323 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-cf2a47a2c6ac4469ba02a0f92452f246 |
| 출처 메모 | uspto-grants-1999_01 |