3-Fluorobenzoyl chloride → HCID 15733509, 화합물

HRID 341862노트

반응식

HRID 341862 반응식
[CH3:1][N:2]([C:4]([NH:6][CH3:7])=[S:5])[NH2:3].[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](Cl)=[O:13]>N1C=CC=CC=1>[CH3:1][N:2]([C:4]([NH:6][CH3:7])=[S:5])[NH:3][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][CH:17]=[C:9]([F:8])[CH:10]=1

참가 물질

4

반응물 2

HCID 743763-Fluorobenzoyl chlorideHCID 30341872,4-Dimethylthiosemicarbazide

생성물 1

HCID 15733509HCID 15733509, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred, room temperature, solution of 2,4-dimethylthiosemicarbazide (5.96 g, 50.0 mmol) and dry pyridine (100 mL) was added dropwise 3-fluorobenzoyl chloride (7.93 g, 50.0 mmol). After stirring overnight, the reaction mixture was evaporated at reduced pressure. The concentrate was slurried with water and that which did not dissolve was collected by filtration. Crystallization of this material from ethanol afforded the desired product as colorless needles, mp 202°-205° C.

후처리

  1. customthe reaction mixture was evaporated at reduced pressure
  2. dissolutiondid not dissolve
  3. filtrationwas collected by filtration
  4. customCrystallization of this material from ethanol

출처 및 근거

ORD 기록
ord-5115182a487c49d49645869cd541a055
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856350

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