Sodium Bicarbonate → Suritozole

HRID 341863노트

반응식

HRID 341863 반응식
[CH3:1][N:2]([C:13]([NH:15][CH3:16])=[S:14])[NH:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=1.C(=O)(O)[O-].[Na+]>>[CH3:1][N:2]1[C:13](=[S:14])[N:15]([CH3:16])[C:4]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=2)=[N:3]1

참가 물질

3

반응물 2

HCID 516892Sodium BicarbonateHCID 15733509HCID 15733509, 화합물

생성물 1

HCID 25431Suritozole

실험 절차

2,4-Dimethyl-l-(3-fluorobenzoyl)thiosemicarbazide (11.1 g, 46.0 mmol) and 1 molar aqueous sodium bicarbonate (460 mL, 0.460 mol) were stirred and heated to reflux. After being refluxed for 5 h, the reaction was allowed to cool to room temperature. After stirring overnight, the reaction was placed in the freezer for several hours. The precipitate was then collected by filtration. Crystallization from isopropanol afforded the desired product as colorless, matted needles, mp 126°-128° C.

후처리

  1. temperatureheated to reflux
  2. temperatureAfter being refluxed for 5 h
  3. waitthe reaction was placed in the freezer for several hours
  4. filtrationThe precipitate was then collected by filtration
  5. customCrystallization from isopropanol

출처 및 근거

ORD 기록
ord-4a08847f177243c6a5dbe6d3e43abe7d
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856350

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