Allyl bromide → 3-Allyloxycarbonyl-5-nitrobenzoic acid

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])([O-:3])=[O:2].[CH2:16](Br)[CH:17]=[CH2:18]>>[CH2:18]([O:14][C:13]([C:6]1[CH:7]=[C:8]([CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:9]([OH:11])=[O:10])=[O:15])[CH:17]=[CH2:16]

참가 물질

반응물 2

HCID 7841Allyl bromide

HCID 120695-Nitroisophthalic acid

생성물 1

HCID 206558603-Allyloxycarbonyl-5-nitrobenzoic acid

실험 절차

5-Nitroisophthalic acid (5 g) was converted to the mono allyl ester using one equivalent of allyl bromide (2 ml) using a similar method to that described in example 1. The required acid (2.7 g) was extracted from the organic phase with aqueous NaHCO3. The organic layer contained the di-allyl ester (2.7 g). The mono acid, 3-allyloxycarbonyl-5-nitrobenzoic acid, was obtained as a white solid. Nmr (CDCl3): 4.87 (d, 2H); 5.3-5.5 (q, 2H); 5.97-6.15 (m, 1H); 9.01 (t, 3H).

후처리

extractionThe required acid (2.7 g) was extracted from the organic phase with aqueous NaHCO3

출처 및 근거

ORD 기록: ord-3b9c539fa1f84be68a147038c98010bb
출처 데이터셋: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05856321

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