Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)aniline → 4-(3'-Trifluoromethyl-4'-nitrophenyl)azobenzeneamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Nitro-alpha,alpha,alpha-trifluoro-o-toluidine | HCID 67128 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 4-(3'-Trifluoromethyl-4'-nitrophenyl)azobenzeneamine | HCID 53859170 | — |
반응 단계
2-Trifluoromethyl-4-nitro-benzeneamine (4.92 g, 23.8 mmol) slurried in 5N hydrochloric acid (15.8 mL) and ice (16 g) was diazotized with 2M sodium nitrite (12.6 mL, 25 mmol) at 0°-5° C., followed by coupling with 3-trifluoromethylbenzeneamine (5.0 g, 31 mmol) in 5N hydrochloric acid (8 mL) at 0°-5° C. The mixture was stirred occasionally for 0.5 h, basified with 25 wt % aqueous potassium carbonate. The resulting solid was recrystallized from THF-ethanol (1:1) to give 4-(3'-trifluoromethyl-4'-nitrophenyl)azobenzeneamine: 1.8 g; mp 144.0°-145.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856431 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-5da6aa39544244489a50b51d8a58e823 |
| 출처 메모 | uspto-grants-1999_01 |