Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dibromobutane → 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Phenylpropanolamine | HCID 10297 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | beta-Methyl-alpha-phenyl-1-pyrrolidineethanol hydrochloride | HCID 53395958 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol | HCID 4079506 | — |
반응 단계
A process for the preparation of [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol hydrochloride or its enantiomer, ##STR53## comprising the steps of: (a) refluxing (1R,2S)-(-)-norephedrine or its enantiomer, ##STR54## with 1,4-dibromobutane in the presence of a base, sodium bicarbonate and a solvent, toluene, at a reaction temperature of about 100° to about 120° C. for reaction time of about 12 to about 24 hours, while removing the water formed to give a toluene solution of crude [R-(R*,S*)]-β-methyl-α-phenyl-1-pyrrolidineethanol or its enantiomer;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856492 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-41089307e971488bb18d503e77f05ecd |
| 출처 메모 | uspto-grants-1999_01 |