Thionyl Chloride → Benzisothiazole

HRID 341974

반응식

HRID 341974 반응식
C[S:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH:5]=[N:6]O.S(Cl)(Cl)=O>ClC1C=CC=CC=1>[S:2]1[C:3]2[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=2[CH:5]=[N:6]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 7867572-(Methylthio)benzaldehyde oxime

생성물 1

HCID 9225Benzisothiazole수율 97%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 33.4 g (0.2 mol) of 2-(methylthio)benzaldehyde oxime was added under nitrogen atmosphere. 25.2 g (0.21 mol) Of thionyl chloride was added dropwise thereto while stirring at a temperature of from -10° to -15° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the reaction mixture was heated to room temperature and subjected to distilling off of the solvent and then to distillation under reduced pressure to give 26.2 g of 1,2-benzisothiazole (boiling point: 115° to 116° C./15 mm Hg, melting point: 39° to 40° C.). The yield was 97% to the 2-(methylthio)benzaldehyde oxime.

후처리

  1. customIn a 300 ml four-necked flask equipped with a stirrer
  2. additionwas added under nitrogen atmosphere
  3. customto react for 1 hour at the same temperature
  4. customAfter the termination of the reaction
  5. distillationto distilling off of the solvent
  6. distillationto distillation under reduced pressure

출처 및 근거

ORD 기록
ord-fddecf631c5f470b9a841324e888c970
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856504

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