Benzisothiazole → 3-Chloro-1,2-benzisothiazole

HRID 341975

반응식

HRID 341975 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.S(Cl)([Cl:13])(=O)=O>ClC1C=CC=CC=1>[Cl:13][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1][N:2]=1

참가 물질

4

반응물 2

HCID 9225BenzisothiazoleHCID 24648Sulfuryl chloride

생성물 1

HCID 5981903-Chloro-1,2-benzisothiazole수율 96%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

In a 300 ml four-necked flask equipped with a stirrer, a thermometer, and a condenser, 100 g of monochlorobenzene was placed in advance, to which 27.0 g (0.2 mol) of 1,2-benzisothiazole was added under nitrogen atmosphere. 32.4 g (0.22 mol) Of sulfuryl chloride was added dropwise thereto while stirring at a temperature of from 70° to 80° C. and allowed to react for 1 hour at the same temperature. After the termination of the reaction, the reaction mixture was subjected to distilling off of the solvent and then to distillation under reduced pressure to give 32.5 g of 3-chloro-1,2-benzisothiazole (boiling point: 116° to 118° C./5 mm Hg, melting point: 38° to 40° C.). The yield was 96% to the 1,2-benzisothiazole.

후처리

  1. customIn a 300 ml four-necked flask equipped with a stirrer
  2. additionwas added under nitrogen atmosphere
  3. customto react for 1 hour at the same temperature
  4. customAfter the termination of the reaction
  5. distillationto distilling off of the solvent
  6. distillationto distillation under reduced pressure

출처 및 근거

ORD 기록
ord-c4037742b9154d1288c92c8b72230c83
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856504

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