Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Malonic Acid → (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Malonic Acid | HCID 867 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde | HCID 2795033 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid | HCID 5343159 | — |
반응 단계
A mixture of 2,3-dihydrobenzodioxin-5-carboxaldehyde (Morishima, et al., Eur. Pat. Appl. 309,766, 5 Apr. 89) (9.25 g, 56.4 mmol), malonic acid (11.73 g, 112.8 mmol), pyrrolidine (1 mL), and pyridine (25 mL) was heated to reflux for 2 hr, cooled, and then poured into ice water (300 mL). The white precipitate was filtered, washed with 1N HCl, and air dried (9.83 g, 84.6%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05856529 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-3eb3b15e0f8746cdb699671094f732a5 |
| 출처 메모 | uspto-grants-1999_01 |