Boron tribromide → 3-(4-Bromo-phenyl)benzofuran-6-ol

HRID 342209노트

반응식

HRID 342209 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17]C)=[CH:16][C:11]=3[O:10][CH:9]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([OH:17])=[CH:16][C:11]=3[O:10][CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 109027443-(4-Bromo-phenyl)-6-methoxy-benzofuran

생성물 1

HCID 545619733-(4-Bromo-phenyl)benzofuran-6-ol수율 101.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.0 g of 3-(4-bromo-phenyl)-6-methoxy-benzofuran are treated at 0° C. with 100 ml of 1M boron tribromide solution in methylene chloride. The ice bath is removed and the reaction mixture is stirred, subsequently poured into saturated sodium carbonate solution and extracted with methylene chloride. The organic phases are washed with saturated sodium chloride solution, dried and evaporated. There are obtained 2.9 g of 3-(4-bromo-phenyl)-benzofuran-6-ol, MS: m/e 288 (M+, 1 Br).

후처리

  1. customThe ice bath is removed
  2. additionsubsequently poured into saturated sodium carbonate solution
  3. extractionextracted with methylene chloride
  4. washThe organic phases are washed with saturated sodium chloride solution
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-eae515a5a6f44a0280d0e37b30718af7
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05856503

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