Iodoacetic Acid → 2-benzoylsulfanylacetic Acid

HRID 342335

반응식

HRID 342335 반응식
[C:1]([OH:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].I[CH2:13][C:14]([OH:16])=[O:15]>C(O)C.O>[C:1]([S:8][CH2:13][C:14]([OH:16])=[O:15])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 5240Iodoacetic AcidHCID 14797Potassium HydroxideHCID 178526132HCID 178526132, 화합물

생성물 1

HCID 51165332-benzoylsulfanylacetic Acid수율 99%

시약·촉매·용매 2

HCID 702Ethanol용매3회HCID 962Water용매

실험 절차

To a purged stirring solution at 0° C. of (5.74 g, 41.6 mmoles) thiobenzoic acid in (100 mL) ethanol was added (27.8 mL, 3N, 83.2 mmoles) potassium hydroxide followed by (7.70 g, 41.6 mmoles) iodoacetic acid in (30 mL) ethanol. The solution stirred for 10 hours at room temperature under argon. The ethanol was rotavapped and the orange solid product was dissolved in (40 mL) water. The solution was acidified to pH 2.0 where an orange precipitate formed. This was filtered, washed with water, and dried in vacuo to give (7.98 g, 99% yield) benzoylmercaptoacetic acid.

후처리

  1. customformed
  2. filtrationThis was filtered
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-ab83a9594a4143f8a4a69464d3ec7286
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858327

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