8-(4-Propylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol → 8-(4-Propylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene

HRID 342349노트

반응식

HRID 342349 반응식
[CH2:1]1[CH2:20][O:19][C:3]2([CH2:8][CH2:7][C:6](O)([C:9]3[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH3:17])=[CH:11][CH:10]=3)[CH2:5][CH2:4]2)[O:2]1>C1(C)C=CC=CC=1>[CH2:20]1[CH2:1][O:2][C:3]2([CH2:4][CH:5]=[C:6]([C:9]3[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][CH3:17])=[CH:13][CH:14]=3)[CH2:7][CH2:8]2)[O:19]1

참가 물질

3

반응물 1

HCID 659181288-(4-Propylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

생성물 1

HCID 675902608-(4-Propylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene수율 98.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To 500 ml of toluene was dissolved 98 g of the 1,1-ethylenedioxy-4-hydroxy-4-(4-n-propylphenyl)cyclohexane mentioned above, 5 g of Amberlist 15E was added as catalyst thereto, and stirred under a reflux for 2 hours. After the reaction solution was cooled, the catalyst was filtered off. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain 90 g of 1,1-ethylenedioxy-4-(4-n-propylphenyl)-4-cyclohexene.

후처리

  1. additionwas added as catalyst
  2. temperaturea reflux for 2 hours
  3. temperatureAfter the reaction solution was cooled
  4. filtrationthe catalyst was filtered off
  5. washOrganic layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationthe solvent was distilled off under a reduced pressure

출처 및 근거

ORD 기록
ord-66d19e8404bc48338104789759baed5f
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858275

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