Ethanol → HCID 178447978, 화합물

HRID 342361노트

반응식

HRID 342361 반응식
[C:1]1([CH3:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]([OH:10])[CH3:9].N1C=CC=CC=1.[CH2:17]([C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26][CH2:27][C@H:28]2[CH2:33][CH2:32][C@H:31](C3C=CC=CC=3C(Cl)=O)[CH2:30][CH2:29]2)[CH2:22][CH2:21]1)[CH2:18][CH3:19].[OH2:43]>>[CH2:17]([C@H:20]1[CH2:21][CH2:22][C@H:23]([CH2:26][CH2:27][C@H:28]2[CH2:33][CH2:32][C@H:31]([CH2:9][CH2:8][O:10][C:7](=[O:43])[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:30][CH2:29]2)[CH2:24][CH2:25]1)[CH2:18][CH3:19]

참가 물질

6

반응물 5

HCID 702EthanolHCID 962WaterHCID 1049PyridineHCID 1140Toluene2회HCID 178447969HCID 178447969, 화합물

생성물 1

HCID 178447978HCID 178447978, 화합물

실험 절차

To 500 ml of toluene was added 5 ml of ethanol and 8 g of pyridine, and they were stirred. Liquid mixture of 18.5 g of the (trans-4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexyl)benzoylchloride mentioned above and 10 ml of toluene was added dropwise thereto, and stirred under a reflux for 2 hours. After it was cooled, the reaction solution was added to 500 ml of water and extracted with 500 ml of toluene. Organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under a reduced pressure to obtain 15.5 g of (trans-4-(2-(trans-4-n-propylcyclohexyl)ethyl)cyclohexyl)ethylbenzoate.

후처리

  1. additionwas added dropwise
  2. stirringstirred under
  3. temperaturea reflux for 2 hours
  4. temperatureAfter it was cooled
  5. extractionextracted with 500 ml of toluene
  6. washOrganic layer was washed with water
  7. dry with materialdried over anhydrous magnesium sulfate
  8. distillationthe solvent was distilled off under a reduced pressure

출처 및 근거

ORD 기록
ord-4592f2e09b424ffd91b3364016e6e794
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858275

반응 노트

불러오는 중…