6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine → 6-(2,6-dichlorophenyl)-2-N-[4-(4-methylpiperazin-1-yl)butyl]pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 3424

반응식

HRID 3424 반응식
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[CH:11]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[C:9]([NH2:20])=[N:8][C:6]=2[N:7]=1.N[CH2:22][CH2:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]1>>[NH2:20][C:9]1[C:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])=[CH:11][C:5]2[CH:4]=[N:3][C:2]([NH:1][CH2:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][N:29]([CH3:32])[CH2:30][CH2:31]3)=[N:7][C:6]=2[N:8]=1

참가 물질

3

반응물 2

HCID 53281136-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamineHCID 64841924-(4-Methylpiperazin-1-yl)butan-1-amine

생성물 1

HCID 53281506-(2,6-dichlorophenyl)-2-N-[4-(4-methylpiperazin-1-yl)butyl]pyrido[2,3-d]pyrimidine-2,7-diamine

실험 절차

Following the procedure of Example 20, 2.0 g of 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine from Example 1 was reacted with 15 mL of 1-(4-aminobutyl)-4-methyl-piperazine to give the title compound.

출처 및 근거

ORD 기록
ord-028f0867c6414e2baa7beafce58df965
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733913

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