Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 70201551, 화합물

HRID 342433

반응식

HRID 342433 반응식
[CH:1]([C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8])=O.[C:16]([CH:21]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:18][CH2:19][CH3:20])=[O:17]>O1CCOCC1>[CH2:19]([O:18][C:16]([CH:21]=[CH:1][C:3]1[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[C:5]=2[O:6][C:7]=1[CH3:8])=[O:17])[CH3:20]

참가 물질

4

반응물 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 867535523-Formyl-2-methyl-7-nitrobenzo[b]furan

생성물 1

HCID 70201551HCID 70201551, 화합물수율 84.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 3-formyl-2-methyl-7-nitrobenzo[b]furan (200 mg) and (carboethoxymethylene)triphenylphosphorane (434 mg) in dioxane (3 ml) was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel. The obtained oil was crystallized from diisopropyl ether to give 3-(2-ethoxycarbonylethenyl)-2-methyl-7-nitrobenzo[b]furan (226 mg).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was purified by column chromatography on silica gel
  3. customThe obtained oil was crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-ef9c129ac1434376ae4f1fb958ae3d48
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05858995

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