4-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine → 1-[3-(Dimethylamino)propyl]piperazine

HRID 342503

반응식

HRID 342503 반응식
C(OC([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:22][N:20]([CH3:21])[CH2:19][CH2:18][CH2:17][N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1

참가 물질

4

반응물 1

HCID 541555964-Benzyloxycarbonyl-3-dimethylaminopropylpiperazine

생성물 1

HCID 27362341-[3-(Dimethylamino)propyl]piperazine수율 97.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4-benzyloxycarbonyl-3-dimethylaminopropylpiperazine (2.21 g, 7.2 mmol), 5% Pd/C (0.36 g) in methanol (20 ml) was stirred under hydrogen atmosphere at room temperature for 38 h. After removal of catalyst by Celite filtration, the filtrate was concentrated to afford 1.20 g (97.6%) of orange color viscous oil.

후처리

  1. customAfter removal of catalyst
  2. filtrationby Celite filtration
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-34838c0e87474c00b0147ee715122c4f
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859011

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