1-nitro-2-(2,2,2-trifluoroethoxy)benzene → 2-(2,2,2-trifluoroethoxy)aniline

HRID 342543

반응식

HRID 342543 반응식
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-])=O>O.[Pt]=O.C(O)C>[F:1][C:2]([F:14])([F:15])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH2:11]

참가 물질

4

반응물 1

HCID 27757681-nitro-2-(2,2,2-trifluoroethoxy)benzene

생성물 1

HCID 27771172-(2,2,2-trifluoroethoxy)aniline수율 80,147.102%

시약·촉매·용매 2

HCID 86587499Platinum oxide monohydrate촉매HCID 702Ethanol용매

반응 조건

온도
25 °C

실험 절차

A mixture of 1-(2,2,2-trifluoroethoxy)-2-nitrobenzene (15 g, 68 mmol), platinum oxide hydrate (100 mg) and absolute ethanol (80 mL) was hydrogenated 18 hours with stirring at 25° C. and 15 psi of pressure. The reaction mixture then was filtered and concentrated. The residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (9:1) to give 2-(2,2,2-trifluoroethoxy)aniline (10.4 g, 54.5 mol), m.p. 49°-50° C.

후처리

  1. filtrationThe reaction mixture then was filtered
  2. concentrationconcentrated
  3. customThe residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (9:1)

출처 및 근거

ORD 기록
ord-4a164bcad9bc47f79b3cc3d17da470f8
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859014

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