Pyridine → 4-(Trifluoromethyl)cinnamoyl chloride

HRID 342613

반응식

HRID 342613 반응식
S(Cl)([Cl:3])=O.[F:5][C:6]([F:19])([F:18])[C:7]1[CH:17]=[CH:16][C:10](/[CH:11]=[CH:12]/[C:13](O)=[O:14])=[CH:9][CH:8]=1.N1C=CC=CC=1>C(Cl)Cl>[F:5][C:6]([F:19])([F:18])[C:7]1[CH:17]=[CH:16][C:10](/[CH:11]=[CH:12]/[C:13]([Cl:3])=[O:14])=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 6880704-(Trifluoromethyl)cinnamic acid

생성물 1

HCID 111072914-(Trifluoromethyl)cinnamoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

Thionyl chloride (335 ml, 4.6 mmol) was added at 0° C. to 4-trifluoromethyl-E-cinnamic acid (1 g, 4.6 mmol) and pyridine (375 ml, 4.6 mmol) in dry CH2Cl2. The mixture was then stirred for 1 h without cooling, again cooled to 0° C. and filtered with the exclusion of moisture. The filtrate (10 ml) contained the title compound and was used in aliquots for the next reaction step.

후처리

  1. temperaturewithout cooling
  2. filtrationfiltered with the exclusion of moisture
  3. customwas used in aliquots for the next reaction step

출처 및 근거

ORD 기록
ord-548f034edc534529847ea7bcc3e082ba
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859025

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