Ammonia → 12-Methoxydodecanamide

HRID 342722

반응식

HRID 342722 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](Cl)=[O:15].[NH3:17]>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH2:17])=[O:15]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 1961175912-Methoxydodecanoyl chloride

생성물 1

HCID 983750412-Methoxydodecanamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To the title product from Example 11 (1.1 g, 4.3 mmol) in 70 mL of anhydrous tetrahydrofuran was added 20 mL of freshly distilled liquid ammonia in a Parr shaker which was sealed and shaken at room temperature for 16 hours. After filtering and concentration, the crude residue was dissolved in anhydrous methanol and passed through a basic ion exchange resin and eluted with anhydrous methanol. Concentration afforded the title compound (780 mg) as a white solid, m.p. 83.9°-85.6° C. (DSC). The structure was supported by NMR, infrared spectroscopy, elemental analysis, and mass spectroscopy.

후처리

  1. customwas sealed
  2. filtrationAfter filtering
  3. concentrationconcentration
  4. dissolutionthe crude residue was dissolved in anhydrous methanol
  5. washeluted with anhydrous methanol
  6. concentrationConcentration

출처 및 근거

ORD 기록
ord-be705ad2343843e6b27e1c2b5957f740
출처 데이터셋
uspto-grants-1999_01
특허 번호
US05859052

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