Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Clavulanic Acid → Potassium Clavulanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Clavulanic Acid | HCID 5280980 | — |
| 반응물 | N,N'-diisopropylethylenediammonium | HCID 7017225 | — |
| 반응물 | Potassium 2-ethylhexanoate | HCID 23669619 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Potassium Clavulanate | HCID 23665591 | 70% |
반응 단계
N,N'-diisopropylethylenediammonium diclavulanate (10 g, clavulanic acid content 69%) was dissolved in water (10 ml), the solution was diluted with isopropanol (190 ml) and a solution (15 ml, 2M) of potassium 2-ethylhexanoate in isopropanol was added within 15 min. with stirring. The obtained suspension was stirred for another 30 min. whereat a precipitate separated, which was filtered off, washed with isopropanol and then dried. Thus there was obtained potassium clavulanate (4.8 g; 70%), (USP Grade, clavulanic acid content 81% as determined by the HPLC method).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05859238 |
| 출처 데이터셋 | uspto-grants-1999_01 |
| ORD ID | ord-721114bda9274c088024b46e36b62efc |
| 출처 메모 | uspto-grants-1999_01 |